Saturday, February 20, 2010
Friday, February 19, 2010
This is very new discovery, but exciting to hear nonetheless!! For full article click here.
LONDON, Feb 18 (Reuters) - Swiss scientists have found a new class of antibiotics, offering drug developers a fresh weapon in the fight against multi-drug resistant bacteria or "superbugs".
Researchers from a privately held Swiss biotech company Polyphor and the University of Zurich said the potential medicines are effective against a type of bacteria known as "gram-negative", and offer hope for new treatments for serious and often life-threatening infections.
The antibiotics work by deactivating a protein vital for the formation of the bacteria's outer cell membrane.
Polyphor's chief financial officer said the firm was in talks with pharmaceutical firms about possible licensing deals on the most advanced drug candidate, called POL7080, which selectively kills the dangerous pseudomonas aeruginosa, a common bacteria that can cause lung infections.
"There is a big need for new antibiotics that can overcome rising resistance," Michael Altorfer told Reuters. "And if you look back in history, finding a new class of antibiotics is an event that probably happens about every 20 years."
Until recently, antibiotics have been viewed by drugmakers as a low-growth area but the emergence of superbugs has rekindled interest in the field.
A study published in the journal Science found that POL7080 was able to target and deactivate an essential protein of the pseudomonas bacteria, killing the bug.
A report in December found that gram-negative bacteria account for around 63 percent of infections in hospital intensive care units. Experts commenting on that study said they feared resistance among gram-negative bugs was rising while the number of medicines to treat them was shrinking. [ID:nN01516996]
Drug-resistant bacteria kill about 25,000 people a year in Europe and about 19,000 in the United States.
Altorfer said Polyphor is planning to start Phase I clinical trials in healthy volunteers in the second quarter of this year and had begun out-licensing negotiations with potential pharma partners. He declined to name any of the firms in talks.
Pseudomonas aeruginosa is a particular problem in hospital acquired infections and in patients with cystic fibrosis, whose lungs and digestive systems become clogged with a thick, sticky mucous.
Altorfer said he was keen not to raise hope, but the drug could potentially be made in an inhalable form to help cystic fibrosis patients, of which there are around 70,000 worldwide.
"But there are other indications that could come first, such as hospital acquired infections," he said.
Full article can be found at http://www.reuters.com/article/idUSLDE61G0OX20100218
Thursday, February 18, 2010
Wednesday, February 17, 2010
Tuesday, February 16, 2010
Young Girl's Post:
Mods, feel free to move this, as I am a teenager, but I'm seeking advice that adults can help with. I have a feeling I've posted things like this before. In Jan, I was in the hospital, got a gtube..lungs went from 50% to 100%. Now, I am not sure..but I believe they are back at 50%. My weight has also dropped a few pounds because the machine was messing up. I don't know what to do with myself. I go into this cycle..hospital is great, but I don't do many of my meds at home. I can't keep doing this, I want to live a long life, and this isn't helping. I feel like crap, when I wake up I DREAD coughing because I know that I will be bringing a lot of stuff up..and many times I end up throwing up because of it. I have zero energy. I get out of breathe going up the stairs... At PE Thursday we I couldn't even run a full lap..I ran 1/4th, after that I felt horrible. What is wrong with me? Why does my mind not want to do these meds? I get so frustrated with myself..but I have no willpower.
I can't stress enough the importance to doing your treatments faithfully at your age. Believe me, we've all been there. I haven't met ONE CFer that is dying to do his or her treatments. I totally agree with previous posters that the future of CF is looking brighter by the day and although there may never be a cure, they WILL come up with a med that takes away many of the affects. The key is to keep your lungs healthy enough so when that day comes, you're lungs are somewhat normal. They've told me that I have a lot of scarring in different areas of my lung. That lung is gone and it's never coming back. Now my focus is to not let any more areas get scarred.
I agree with coming up with a routine. Maybe every morning you sit on your vest and do the nebs while doing something on the computer? Homework? Facebook? Myspace? Personal blog? Do you watch TV? Every time your show comes on, make it a habit to do your treatments while watching it.
I figure that anytime I sit down, I can be doing my treatments. Believe me, it wasn't this was when I was your age, but if I could turn back the clock and do it over again I would. I'm paying the price now, for my neglect in the past.
I really hope this helps and you can message me if you'd like to talk further.
Readers: What would your response have been?